Preparation and Characterization of Natural Antioxidant Emulgels Loaded with Annona squamosa L. Extract with and without Penetration Enhancer

Highly sustainable emulgels loaded with Annona squamosa L. extract with and without penetration enhancer were formulated. Characterization evaluations of prepared emulgels formulations were done at various storage conditions. Acetone (70%) was used to prepare Annona squamosa L. extract by using maceration technique. Emulgels were prepared by using 4% extract with and without penetration enhancer (clove oil 8%). Varying concentrations of carbapol 940 (0.5-2%) were used in the development of emulgels. All the formulations were kept first at 25°C and then stressed at 40°C to sort out the most stable formulation. The in vitro characterization of the optimized formulation was done including pH, conductivity, phase separation, and mean droplet size. These parameters were monitoring over a period of 90 days at 8°C, 25°C, 40°C and 40°C with 75 % RH.