Synthesis and Pharmacological Activity of Some Pyrazolone Derivatives

A sequence of novel pyrazolone derivative was produced by the reaction of 2, 4-dinitrophenyl hydrazine (0.1 mol) and ethyl acetoacetate with benzaldehydes followed by hydrazine hydrate and finally treated with secondary amine and formaldehyde and the synthesized compounds were characterized by their physical properties (M.P and TLC) and UV, IR, 1HNMR, Mass spectroscopic studies respectively. The entire synthesized complex was tested for their anthelmintic, antimicrobial and haemostatic activity against gram-positive and gram-negative strains of bacteria and Eudrilus eugenia and human venous blood. The antimicrobial activity of synthesized pyrazolone derivatives was assessed by agar cup method. All the synthesized complexes were screened for the antimicrobial, athelmintic and haemostatic activity against some gram (+ve), Gram(-ve) organisms, Eudrilus eugenia and human venous blood. The complexes exhibited reasonable to upright activity when compared with the standard one.